Drug interactions
Metformin-sitagliptin + Quinidine
Severity: Moderate
Metformin-sitagliptin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine can raise metformin exposure by reducing its renal elimination. Higher metformin levels may increase the risk of adverse effects including lactic acidosis, particularly with renal impairment.
What this interaction means in plain words
Metformin-sitagliptin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine, a cationic drug, competes with metformin for renal tubular secretion via OCT2 and MATE transporters.
What to do
Monitor glycemic control and renal function, and reduce the metformin dose if adverse effects or reduced renal function occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Quinidine?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine can raise metformin exposure by reducing its renal elimination. Higher metformin levels may increase the risk of adverse effects including lactic acidosis, particularly with renal impairment.
How serious is the interaction between Metformin-sitagliptin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and reduce the metformin dose if adverse effects or reduced renal function occur.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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