Drug interactions
Metformin-sitagliptin + Sarecycline
Severity: Minor
Metformin-sitagliptin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is described as a weak P-glycoprotein inhibitor, which could modestly raise sitagliptin exposure. Sitagliptin has a wide safety margin, so a clinically important effect is unlikely.
What this interaction means in plain words
Metformin-sitagliptin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible inhibition of P-glycoprotein-mediated efflux of sitagliptin.
What to do
No dose change is normally needed. Be aware of the potential for increased sitagliptin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Metformin-sitagliptin with Sarecycline?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is described as a weak P-glycoprotein inhibitor, which could modestly raise sitagliptin exposure. Sitagliptin has a wide safety margin, so a clinically important effect is unlikely.
How serious is the interaction between Metformin-sitagliptin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Be aware of the potential for increased sitagliptin adverse effects.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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