Drug interactions
Metformin-sitagliptin + Tafenoquine
Severity: Moderate
Metformin-sitagliptin and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits the renal transporters OCT2 and MATE, which clear metformin. Metformin concentrations may rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in patients with reduced renal function.
What this interaction means in plain words
Metformin-sitagliptin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE transporters, reducing renal tubular secretion of metformin.
What to do
Monitor for metformin toxicity and glycemic control, and consider reducing the metformin dose. Avoid the combination in patients with impaired renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-sitagliptin and Tafenoquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Metformin-sitagliptin with Tafenoquine?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits the renal transporters OCT2 and MATE, which clear metformin. Metformin concentrations may rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in patients with reduced renal function.
How serious is the interaction between Metformin-sitagliptin and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin toxicity and glycemic control, and consider reducing the metformin dose. Avoid the combination in patients with impaired renal function.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
