Drug interactions
Metformin-sitagliptin + Verapamil
Severity: Minor
Metformin-sitagliptin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may reduce the glucose-lowering effect of metformin by limiting its uptake into hepatocytes. The effect is modest and variable.
What this interaction means in plain words
Metformin-sitagliptin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits OCT1-mediated hepatic uptake of metformin.
What to do
Monitor glycemic control when verapamil is started or stopped and adjust metformin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Metformin-sitagliptin with Verapamil?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may reduce the glucose-lowering effect of metformin by limiting its uptake into hepatocytes. The effect is modest and variable.
How serious is the interaction between Metformin-sitagliptin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when verapamil is started or stopped and adjust metformin dose if needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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