Drug interactions
Methadone + Nifedipine
Severity: Minor
Methadone and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may modestly raise methadone exposure, although the clinical significance is uncertain. Both agents can also cause hypotension and dizziness, which could add together.
What this interaction means in plain words
Methadone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methadone belongs to Musculoskeletal; Nifedipine belongs to Cardiovascular.
Why it happens
Possible weak competition for CYP3A4 metabolism, and additive blood pressure lowering.
What to do
Monitor blood pressure and for excess sedation when starting or adjusting nifedipine in patients on methadone. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Methadone with Nifedipine?
MediHelp rates the interaction as minor. Methadone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine may modestly raise methadone exposure, although the clinical significance is uncertain. Both agents can also cause hypotension and dizziness, which could add together.
How serious is the interaction between Methadone and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for excess sedation when starting or adjusting nifedipine in patients on methadone. No routine dose change is required.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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