Drug interactions
Methadone + Ofloxacin
Severity: Moderate
Methadone and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use raises the risk of torsades de pointes, especially with other risk factors. Ofloxacin carries a lower QT risk than some other fluoroquinolones.
What this interaction means in plain words
Methadone and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac potassium channel (hERG) blockade.
What to do
Consider a baseline ECG and correct hypokalemia and hypomagnesemia. Choose a non-QT-prolonging antibiotic if the patient has other risk factors or a prolonged QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Methadone with Ofloxacin?
MediHelp rates the interaction as moderate. Methadone and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use raises the risk of torsades de pointes, especially with other risk factors. Ofloxacin carries a lower QT risk than some other fluoroquinolones.
How serious is the interaction between Methadone and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG and correct hypokalemia and hypomagnesemia. Choose a non-QT-prolonging antibiotic if the patient has other risk factors or a prolonged QTc.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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