Drug interactions
Methadone + Suvorexant
Severity: Moderate
Methadone and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs produce additive sedation and impaired psychomotor function, with a risk of next-day drowsiness and respiratory depression.
What this interaction means in plain words
Methadone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and orexin receptor antagonism.
What to do
Use the lowest effective suvorexant dose and monitor for excessive sedation and respiratory depression. Warn patients about driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Methadone with Suvorexant?
MediHelp rates the interaction as moderate. Methadone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these drugs produce additive sedation and impaired psychomotor function, with a risk of next-day drowsiness and respiratory depression.
How serious is the interaction between Methadone and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and monitor for excessive sedation and respiratory depression. Warn patients about driving and other hazardous activities.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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