Drug interactions
Methadone + Telavancin
Severity: Moderate
Methadone and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of torsades de pointes. The risk is higher with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Methadone and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation through delayed cardiac repolarization (hERG potassium channel blockade by methadone, QT effect of telavancin).
What to do
Obtain a baseline ECG and repeat it during telavancin therapy, and correct potassium and magnesium. Consider an alternative antibiotic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Methadone with Telavancin?
MediHelp rates the interaction as moderate. Methadone and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may add to the risk of torsades de pointes. The risk is higher with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Methadone and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during telavancin therapy, and correct potassium and magnesium. Consider an alternative antibiotic if the QTc becomes markedly prolonged.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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