Drug interactions
Methocarbamol + Orphenadrine
Severity: Moderate
Methocarbamol and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are centrally acting skeletal muscle relaxants, so using them together gives duplicate therapy with greater drowsiness and dizziness. Orphenadrine also adds anticholinergic effects such as confusion, dry mouth and urinary retention, especially in older patients.
What this interaction means in plain words
Methocarbamol and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus anticholinergic effects from orphenadrine.
What to do
Avoid using two muscle relaxants together; choose one agent. If unavoidable, monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Frequently asked questions
Can I take Methocarbamol with Orphenadrine?
MediHelp rates the interaction as moderate. Methocarbamol and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are centrally acting skeletal muscle relaxants, so using them together gives duplicate therapy with greater drowsiness and dizziness. Orphenadrine also adds anticholinergic effects such as confusion, dry mouth and urinary retention, especially in older patients.
How serious is the interaction between Methocarbamol and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two muscle relaxants together; choose one agent. If unavoidable, monitor for sedation and anticholinergic effects.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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