Drug interactions
Methocarbamol + Pholcodine
Severity: Moderate
Methocarbamol and Pholcodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid antitussive with mild sedative properties, and methocarbamol may add to drowsiness. Respiratory depression is uncommon at antitussive doses but possible with higher doses.
What this interaction means in plain words
Methocarbamol and Pholcodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive drowsiness and advise against driving if affected. Avoid exceeding recommended doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Frequently asked questions
Can I take Methocarbamol with Pholcodine?
MediHelp rates the interaction as moderate. Methocarbamol and Pholcodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pholcodine is an opioid antitussive with mild sedative properties, and methocarbamol may add to drowsiness. Respiratory depression is uncommon at antitussive doses but possible with higher doses.
How serious is the interaction between Methocarbamol and Pholcodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and advise against driving if affected. Avoid exceeding recommended doses.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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