Drug interactions
Methocarbamol + Quazepam
Severity: Major
Methocarbamol and Quazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and methocarbamol adds further CNS depression. This can cause next-day drowsiness, impaired coordination, falls and, rarely, respiratory depression.
What this interaction means in plain words
Methocarbamol and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A enhancement and central muscle relaxation.
What to do
Use the lowest effective doses and monitor for sedation and falls, especially in older adults. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methocarbamol
Frequently asked questions
Can I take Methocarbamol with Quazepam?
MediHelp rates the interaction as major. Methocarbamol and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quazepam is a long-acting benzodiazepine hypnotic, and methocarbamol adds further CNS depression. This can cause next-day drowsiness, impaired coordination, falls and, rarely, respiratory depression.
How serious is the interaction between Methocarbamol and Quazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and falls, especially in older adults. Avoid alcohol and other sedatives.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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