Drug interactions
Methohexital + Pimozide
Severity: Moderate
Methohexital and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic, and pimozide can add to its sedative and respiratory depressant effects. Hypotension and prolonged recovery may also occur.
What this interaction means in plain words
Methohexital and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Titrate methohexital carefully, with continuous monitoring of ventilation and blood pressure. Anticipate a reduced anesthetic dose requirement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Pimozide?
MediHelp rates the interaction as moderate. Methohexital and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic, and pimozide can add to its sedative and respiratory depressant effects. Hypotension and prolonged recovery may also occur.
How serious is the interaction between Methohexital and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully, with continuous monitoring of ventilation and blood pressure. Anticipate a reduced anesthetic dose requirement.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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