Drug interactions
Methohexital + Remifentanil
Severity: Moderate
Methohexital and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic and remifentanil is an ultra-short-acting opioid. Together they produce additive sedation, respiratory depression and hypotension. This is often exploited in anesthesia but needs a controlled setting.
What this interaction means in plain words
Methohexital and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression through GABA-A potentiation by the barbiturate and mu-opioid agonism.
What to do
Use only where airway management and ventilatory support are available, and titrate each drug to effect. Monitor blood pressure, oxygen saturation and respiratory rate continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Remifentanil?
MediHelp rates the interaction as moderate. Methohexital and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic and remifentanil is an ultra-short-acting opioid. Together they produce additive sedation, respiratory depression and hypotension. This is often exploited in anesthesia but needs a controlled setting.
How serious is the interaction between Methohexital and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway management and ventilatory support are available, and titrate each drug to effect. Monitor blood pressure, oxygen saturation and respiratory rate continuously.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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