Drug interactions
Methohexital + Topiramate
Severity: Moderate
Methohexital and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate may add to the sedative and respiratory depressant effects of methohexital. Recovery from anesthesia may be prolonged.
What this interaction means in plain words
Methohexital and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression through enhanced GABAergic activity.
What to do
Titrate methohexital to effect with reduced doses if needed and monitor respiration and level of consciousness until fully recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Topiramate?
MediHelp rates the interaction as moderate. Methohexital and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate may add to the sedative and respiratory depressant effects of methohexital. Recovery from anesthesia may be prolonged.
How serious is the interaction between Methohexital and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect with reduced doses if needed and monitor respiration and level of consciousness until fully recovered.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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