Drug interactions
Methotrexate + Pexidartinib
Severity: Major
Methotrexate and Pexidartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause liver injury, and pexidartinib carries a boxed warning for serious hepatotoxicity. Combining them may increase the risk of liver damage.
What this interaction means in plain words
Methotrexate and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methotrexate belongs to Oncology; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two drugs that can independently injure the liver.
What to do
Avoid the combination where possible. If both are needed, monitor liver tests frequently and stop at signs of hepatotoxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Methotrexate with Pexidartinib?
MediHelp rates the interaction as major. Methotrexate and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause liver injury, and pexidartinib carries a boxed warning for serious hepatotoxicity. Combining them may increase the risk of liver damage.
How serious is the interaction between Methotrexate and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, monitor liver tests frequently and stop at signs of hepatotoxicity.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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