Drug interactions
Methotrexate + Pneumococcal vaccine 13-valent
Severity: Moderate
Methotrexate and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can lower the antibody response to pneumococcal vaccination. The vaccine is non-live and remains safe to give, but protection may be reduced.
What this interaction means in plain words
Methotrexate and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Immunosuppression reducing vaccine-induced antibody production.
What to do
Give the vaccine, ideally before starting methotrexate, and do not withhold it in treated patients. Consider a short methotrexate hold only if specialist guidance supports it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Methotrexate with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Methotrexate and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate can lower the antibody response to pneumococcal vaccination. The vaccine is non-live and remains safe to give, but protection may be reduced.
How serious is the interaction between Methotrexate and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine, ideally before starting methotrexate, and do not withhold it in treated patients. Consider a short methotrexate hold only if specialist guidance supports it.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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