Drug interactions
Methotrexate + Regorafenib
Severity: Moderate
Methotrexate and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP, a transporter involved in methotrexate efflux, potentially increasing methotrexate exposure and toxicity such as myelosuppression and mucositis. Clinical data are limited.
What this interaction means in plain words
Methotrexate and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Inhibition of BCRP (ABCG2)-mediated efflux of methotrexate by regorafenib.
What to do
Monitor blood counts, renal and liver function and signs of methotrexate toxicity; consider lowering the methotrexate dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Regorafenib
Frequently asked questions
Can I take Methotrexate with Regorafenib?
MediHelp rates the interaction as moderate. Methotrexate and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP, a transporter involved in methotrexate efflux, potentially increasing methotrexate exposure and toxicity such as myelosuppression and mucositis. Clinical data are limited.
How serious is the interaction between Methotrexate and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal and liver function and signs of methotrexate toxicity; consider lowering the methotrexate dose if toxicity appears.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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