Drug interactions
Methotrexate + Sarecycline
Severity: Moderate
Methotrexate and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is predicted to inhibit P-glycoprotein and could modestly raise methotrexate levels. Tetracycline-class antibiotics have also been linked to methotrexate toxicity in case reports.
What this interaction means in plain words
Methotrexate and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Inhibition of P-gp efflux may increase methotrexate absorption and reduce elimination.
What to do
Monitor for methotrexate toxicity with blood counts and liver and renal function. Reduce methotrexate dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Methotrexate with Sarecycline?
MediHelp rates the interaction as moderate. Methotrexate and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sarecycline is predicted to inhibit P-glycoprotein and could modestly raise methotrexate levels. Tetracycline-class antibiotics have also been linked to methotrexate toxicity in case reports.
How serious is the interaction between Methotrexate and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for methotrexate toxicity with blood counts and liver and renal function. Reduce methotrexate dose if toxicity occurs.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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