Drug interactions
Methotrexate + Voclosporin
Severity: Moderate
Methotrexate and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can reduce renal function. Methotrexate is renally eliminated, so impaired kidney function may raise its levels and toxicity, while both may add to nephrotoxicity.
What this interaction means in plain words
Methotrexate and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of methotrexate secondary to calcineurin inhibitor-induced renal impairment.
What to do
Monitor serum creatinine, eGFR and blood counts regularly. Reduce or hold methotrexate if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Methotrexate with Voclosporin?
MediHelp rates the interaction as moderate. Methotrexate and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can reduce renal function. Methotrexate is renally eliminated, so impaired kidney function may raise its levels and toxicity, while both may add to nephrotoxicity.
How serious is the interaction between Methotrexate and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, eGFR and blood counts regularly. Reduce or hold methotrexate if renal function declines.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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