Drug interactions
Methotrexate + Zidovudine
Severity: Moderate
Methotrexate and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress the bone marrow, so combined use may increase the risk of anemia, neutropenia and infection.
What this interaction means in plain words
Methotrexate and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts frequently. Reduce doses, interrupt treatment or use an alternative antiretroviral if significant cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Methotrexate with Zidovudine?
MediHelp rates the interaction as moderate. Methotrexate and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can suppress the bone marrow, so combined use may increase the risk of anemia, neutropenia and infection.
How serious is the interaction between Methotrexate and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently. Reduce doses, interrupt treatment or use an alternative antiretroviral if significant cytopenias occur.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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