Drug interactions
Methoxsalen + Methyclothiazide
Severity: Moderate
Methoxsalen and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of phototoxic reactions such as erythema and burns.
What this interaction means in plain words
Methoxsalen and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects (pharmacodynamic).
What to do
Counsel on strict sun avoidance and photoprotection, and adjust UVA dosing based on skin response. Consider an alternative antihypertensive or diuretic if phototoxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Methyclothiazide?
MediHelp rates the interaction as moderate. Methoxsalen and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of phototoxic reactions such as erythema and burns.
How serious is the interaction between Methoxsalen and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict sun avoidance and photoprotection, and adjust UVA dosing based on skin response. Consider an alternative antihypertensive or diuretic if phototoxicity occurs.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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