Drug interactions
Methoxsalen + Midazolam intranasal
Severity: Moderate
Methoxsalen and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen inhibits CYP3A4, which may increase systemic midazolam exposure. This can prolong sedation and increase respiratory depression risk.
What this interaction means in plain words
Methoxsalen and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated midazolam metabolism by methoxsalen.
What to do
Monitor sedation level and respiratory status for longer than usual after a dose. Avoid repeat dosing earlier than usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Midazolam intranasal?
MediHelp rates the interaction as moderate. Methoxsalen and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen inhibits CYP3A4, which may increase systemic midazolam exposure. This can prolong sedation and increase respiratory depression risk.
How serious is the interaction between Methoxsalen and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status for longer than usual after a dose. Avoid repeat dosing earlier than usual.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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