Drug interactions
Methoxsalen + Olanzapine / samidorphan
Severity: Moderate
Methoxsalen and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen is a potent CYP1A2 inhibitor and can raise olanzapine concentrations, increasing sedation, orthostasis and other adverse effects.
What this interaction means in plain words
Methoxsalen and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated olanzapine metabolism by methoxsalen.
What to do
Monitor for sedation and hypotension and consider reducing the olanzapine dose during methoxsalen therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Methoxsalen and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen is a potent CYP1A2 inhibitor and can raise olanzapine concentrations, increasing sedation, orthostasis and other adverse effects.
How serious is the interaction between Methoxsalen and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and hypotension and consider reducing the olanzapine dose during methoxsalen therapy.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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