Drug interactions
Methoxsalen + Sulfadiazine
Severity: Moderate
Methoxsalen and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamides can cause photosensitivity, and with methoxsalen plus UVA the phototoxic response may be heightened. This can result in exaggerated sunburn-like reactions.
What this interaction means in plain words
Methoxsalen and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects (pharmacodynamic).
What to do
Counsel on sun avoidance and protective clothing, and lower the UVA dose if erythema develops. Consider a non-photosensitizing antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Sulfadiazine?
MediHelp rates the interaction as moderate. Methoxsalen and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamides can cause photosensitivity, and with methoxsalen plus UVA the phototoxic response may be heightened. This can result in exaggerated sunburn-like reactions.
How serious is the interaction between Methoxsalen and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sun avoidance and protective clothing, and lower the UVA dose if erythema develops. Consider a non-photosensitizing antibiotic if possible.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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