Drug interactions
Methoxsalen + Sulfisoxazole
Severity: Moderate
Methoxsalen and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole, a sulfonamide, can cause photosensitivity and may add to the phototoxic effect of methoxsalen with UVA. This raises the risk of severe sunburn-like reactions.
What this interaction means in plain words
Methoxsalen and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects (pharmacodynamic).
What to do
Counsel on sun avoidance and monitor skin response, adjusting the UVA dose accordingly. Choose a non-photosensitizing alternative if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Sulfisoxazole?
MediHelp rates the interaction as moderate. Methoxsalen and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole, a sulfonamide, can cause photosensitivity and may add to the phototoxic effect of methoxsalen with UVA. This raises the risk of severe sunburn-like reactions.
How serious is the interaction between Methoxsalen and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sun avoidance and monitor skin response, adjusting the UVA dose accordingly. Choose a non-photosensitizing alternative if possible.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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