Drug interactions
Methoxsalen + Trifluoperazine
Severity: Moderate
Methoxsalen and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as trifluoperazine can cause photosensitivity. With methoxsalen and UVA, phototoxic reactions may be more severe.
What this interaction means in plain words
Methoxsalen and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects (pharmacodynamic).
What to do
Advise strict photoprotection and reduce UVA dosing if erythema occurs. Review need for the phenothiazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Trifluoperazine?
MediHelp rates the interaction as moderate. Methoxsalen and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as trifluoperazine can cause photosensitivity. With methoxsalen and UVA, phototoxic reactions may be more severe.
How serious is the interaction between Methoxsalen and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict photoprotection and reduce UVA dosing if erythema occurs. Review need for the phenothiazine.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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