Drug interactions
Methoxyflurane + Neomycin
Severity: Major
Methoxyflurane and Neomycin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride during metabolism and can cause renal tubular toxicity. Oral neomycin is usually poorly absorbed but can reach significant systemic levels when the gut is inflamed or renal function is reduced, adding to kidney and ear toxicity.
What this interaction means in plain words
Methoxyflurane and Neomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from fluoride-mediated tubular injury and aminoglycoside accumulation in the kidney, with ototoxicity when neomycin is absorbed.
What to do
Avoid combining where possible, especially in renal impairment or bowel disease. If used together, monitor renal function and hearing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Methoxyflurane with Neomycin?
MediHelp rates the interaction as major. Methoxyflurane and Neomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane releases fluoride during metabolism and can cause renal tubular toxicity. Oral neomycin is usually poorly absorbed but can reach significant systemic levels when the gut is inflamed or renal function is reduced, adding to kidney and ear toxicity.
How serious is the interaction between Methoxyflurane and Neomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in renal impairment or bowel disease. If used together, monitor renal function and hearing.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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