Drug interactions
Methoxyflurane + Secobarbital
Severity: Major
Methoxyflurane and Secobarbital: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can raise conversion of methoxyflurane to nephrotoxic fluoride metabolites. This increases the risk of renal injury. Additive CNS depression also occurs.
What this interaction means in plain words
Methoxyflurane and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Hepatic enzyme induction increases methoxyflurane biotransformation to nephrotoxic metabolites.
What to do
Avoid using methoxyflurane in patients on barbiturates where possible. If it is used, keep exposure to the minimum and monitor renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Methoxyflurane with Secobarbital?
MediHelp rates the interaction as major. Methoxyflurane and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce hepatic enzymes and can raise conversion of methoxyflurane to nephrotoxic fluoride metabolites. This increases the risk of renal injury. Additive CNS depression also occurs.
How serious is the interaction between Methoxyflurane and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using methoxyflurane in patients on barbiturates where possible. If it is used, keep exposure to the minimum and monitor renal function.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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