Drug interactions
Methoxyflurane + Vancomycin
Severity: Moderate
Methoxyflurane and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane causes dose-related nephrotoxicity through fluoride release, and combining it with vancomycin may add to kidney injury risk. Methoxyflurane is now used only in low-dose analgesic inhalers in some regions.
What this interaction means in plain words
Methoxyflurane and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with methoxyflurane metabolites such as fluoride damaging renal tubules.
What to do
Avoid combined use in patients with renal impairment and monitor serum creatinine if the combination is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Methoxyflurane with Vancomycin?
MediHelp rates the interaction as moderate. Methoxyflurane and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxyflurane causes dose-related nephrotoxicity through fluoride release, and combining it with vancomycin may add to kidney injury risk. Methoxyflurane is now used only in low-dose analgesic inhalers in some regions.
How serious is the interaction between Methoxyflurane and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use in patients with renal impairment and monitor serum creatinine if the combination is necessary.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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