Drug interactions
Methyclothiazide + Oxaprozin
Severity: Moderate
Methyclothiazide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of thiazides through sodium and water retention, and they add to the risk of kidney injury when volume is depleted. Potassium effects are opposed and of minor importance.
What this interaction means in plain words
Methyclothiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces natriuresis and renal blood flow, antagonizing thiazide effect.
What to do
Monitor blood pressure, fluid status and renal function when starting or stopping oxaprozin. Ensure adequate hydration and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Methyclothiazide with Oxaprozin?
MediHelp rates the interaction as moderate. Methyclothiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effect of thiazides through sodium and water retention, and they add to the risk of kidney injury when volume is depleted. Potassium effects are opposed and of minor importance.
How serious is the interaction between Methyclothiazide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function when starting or stopping oxaprozin. Ensure adequate hydration and adjust antihypertensive therapy if control is lost.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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