Drug interactions
Methyclothiazide + Tolazamide
Severity: Moderate
Methyclothiazide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may partly offset the effect of sulfonylureas, so glycemic control may worsen. The effect is dose-related and usually modest, but it can require adjustment of diabetes therapy.
What this interaction means in plain words
Methyclothiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and peripheral insulin sensitivity oppose the glucose-lowering action of tolazamide.
What to do
Monitor blood glucose and potassium when a thiazide is started or its dose changed. Increase the tolazamide dose or use a lower thiazide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Methyclothiazide with Tolazamide?
MediHelp rates the interaction as moderate. Methyclothiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and may partly offset the effect of sulfonylureas, so glycemic control may worsen. The effect is dose-related and usually modest, but it can require adjustment of diabetes therapy.
How serious is the interaction between Methyclothiazide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when a thiazide is started or its dose changed. Increase the tolazamide dose or use a lower thiazide dose if control worsens.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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