Drug interactions
Methyclothiazide + Tolbutamide
Severity: Moderate
Methyclothiazide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, and may reduce the effectiveness of sulfonylureas. Loss of glycemic control may require a change in diabetes therapy.
What this interaction means in plain words
Methyclothiazide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose the glucose-lowering effect of tolbutamide.
What to do
Monitor blood glucose and serum potassium, and increase the tolbutamide dose or use the lowest effective thiazide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Methyclothiazide with Tolbutamide?
MediHelp rates the interaction as moderate. Methyclothiazide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose, particularly at higher doses, and may reduce the effectiveness of sulfonylureas. Loss of glycemic control may require a change in diabetes therapy.
How serious is the interaction between Methyclothiazide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and increase the tolbutamide dose or use the lowest effective thiazide dose if control worsens.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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