Drug interactions
Methyclothiazide + Umeclidinium-vilanterol
Severity: Moderate
Methyclothiazide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and beta2-agonists such as vilanterol can each lower potassium. Together they may cause hypokalemia and ECG changes, particularly at high doses.
What this interaction means in plain words
Methyclothiazide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from thiazide renal potassium loss and beta2-mediated intracellular potassium shift.
What to do
Check serum potassium periodically and supplement as needed; avoid exceeding the recommended vilanterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Methyclothiazide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Methyclothiazide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and beta2-agonists such as vilanterol can each lower potassium. Together they may cause hypokalemia and ECG changes, particularly at high doses.
How serious is the interaction between Methyclothiazide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium periodically and supplement as needed; avoid exceeding the recommended vilanterol dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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