Drug interactions
Methyldopa + Pseudoephedrine
Severity: Moderate
Methyldopa and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine can raise blood pressure and may counteract the antihypertensive effect of methyldopa. Sympathomimetic pressor responses may also be altered unpredictably by methyldopa.
What this interaction means in plain words
Methyldopa and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methyldopa belongs to Cardiovascular; Pseudoephedrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism of antihypertensive effect; methyldopa may also alter pressor responsiveness to sympathomimetics.
What to do
Monitor blood pressure when pseudoephedrine is used; avoid it in patients with poorly controlled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Frequently asked questions
Can I take Methyldopa with Pseudoephedrine?
MediHelp rates the interaction as moderate. Methyldopa and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine can raise blood pressure and may counteract the antihypertensive effect of methyldopa. Sympathomimetic pressor responses may also be altered unpredictably by methyldopa.
How serious is the interaction between Methyldopa and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when pseudoephedrine is used; avoid it in patients with poorly controlled hypertension.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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