Drug interactions
Methylenedioxymethamphetamine + Orphenadrin
Severity: Moderate
Methylenedioxymethamphetamine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a stimulant with serotonergic and sympathomimetic effects, while orphenadrine is sedating and anticholinergic. Both can raise heart rate and impair temperature regulation, so the combination may increase the risk of tachycardia and hyperthermia.
What this interaction means in plain words
Methylenedioxymethamphetamine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing sedative and stimulant effects with additive anticholinergic impairment of heat dissipation; not well characterized.
What to do
Advise avoiding MDMA while on orphenadrine, and monitor heart rate, temperature and hydration status if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Orphenadrin?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a stimulant with serotonergic and sympathomimetic effects, while orphenadrine is sedating and anticholinergic. Both can raise heart rate and impair temperature regulation, so the combination may increase the risk of tachycardia and hyperthermia.
How serious is the interaction between Methylenedioxymethamphetamine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding MDMA while on orphenadrine, and monitor heart rate, temperature and hydration status if exposure occurs.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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