Drug interactions
Methylenedioxymethamphetamine + Quetiapine
Severity: Moderate
Methylenedioxymethamphetamine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is an illicit serotonergic stimulant that can cause hyperthermia, tachycardia and arrhythmia. Quetiapine may add to cardiac conduction effects and may complicate management of toxicity. The effects are unpredictable and the data are limited.
What this interaction means in plain words
Methylenedioxymethamphetamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing and overlapping serotonergic, dopaminergic and cardiovascular pharmacodynamic effects; not well characterized.
What to do
Counsel against recreational MDMA use during quetiapine therapy. In suspected toxicity, monitor temperature, ECG and mental status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Quetiapine?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is an illicit serotonergic stimulant that can cause hyperthermia, tachycardia and arrhythmia. Quetiapine may add to cardiac conduction effects and may complicate management of toxicity. The effects are unpredictable and the data are limited.
How serious is the interaction between Methylenedioxymethamphetamine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against recreational MDMA use during quetiapine therapy. In suspected toxicity, monitor temperature, ECG and mental status.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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