Drug interactions
Methylergonovine + Sumatriptan
Severity: Contraindicated
Methylergonovine and Sumatriptan: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is a potent ergot vasoconstrictor, and combining it with sumatriptan can cause additive, prolonged arterial spasm. This may lead to myocardial or cerebral ischemia, or peripheral ischemia.
What this interaction means in plain words
Methylergonovine and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction through serotonin receptor agonism by both drugs and adrenergic and serotonergic effects of the ergot.
What to do
Do not give the two within 24 hours of each other. In postpartum hemorrhage use a non-ergot uterotonic such as oxytocin or carboprost if a triptan was recently taken.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Methylergonovine with Sumatriptan?
MediHelp rates the interaction as contraindicated. Methylergonovine and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylergonovine is a potent ergot vasoconstrictor, and combining it with sumatriptan can cause additive, prolonged arterial spasm. This may lead to myocardial or cerebral ischemia, or peripheral ischemia.
How serious is the interaction between Methylergonovine and Sumatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the two within 24 hours of each other. In postpartum hemorrhage use a non-ergot uterotonic such as oxytocin or carboprost if a triptan was recently taken.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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