Drug interactions
Methylergonovine + Ziprasidone
Severity: Minor
Methylergonovine and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is an ergot derivative with serotonergic and vasoconstrictive activity and is metabolized by CYP3A4, and ziprasidone is a weak CYP3A4 substrate that does not meaningfully inhibit it. Serotonin syndrome or neuroleptic malignant syndrome is only a theoretical concern with short courses.
What this interaction means in plain words
Methylergonovine and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic overlap at serotonin and dopamine receptors; no established pharmacokinetic interaction.
What to do
Monitor for agitation, hyperthermia, rigidity and autonomic instability during the short postpartum course. No dose adjustment is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Methylergonovine with Ziprasidone?
MediHelp rates the interaction as minor. Methylergonovine and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylergonovine is an ergot derivative with serotonergic and vasoconstrictive activity and is metabolized by CYP3A4, and ziprasidone is a weak CYP3A4 substrate that does not meaningfully inhibit it. Serotonin syndrome or neuroleptic malignant syndrome is only a theoretical concern with short courses.
How serious is the interaction between Methylergonovine and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity and autonomic instability during the short postpartum course. No dose adjustment is normally needed.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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