Drug interactions
Metipranolol + Verapamil
Severity: Moderate
Metipranolol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ophthalmic metipranolol is a beta-blocker with some systemic absorption, and with oral verapamil it can add to bradycardia and AV block. Cases of marked bradycardia and conduction disturbance have been described with ophthalmic beta-blockers and verapamil.
What this interaction means in plain words
Metipranolol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic, dromotropic and inotropic effects of beta-blockade and calcium channel blockade.
What to do
Monitor heart rate, ECG and blood pressure, especially in patients with conduction disease or heart failure; consider a non-beta-blocker glaucoma agent if bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Metipranolol with Verapamil?
MediHelp rates the interaction as moderate. Metipranolol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ophthalmic metipranolol is a beta-blocker with some systemic absorption, and with oral verapamil it can add to bradycardia and AV block. Cases of marked bradycardia and conduction disturbance have been described with ophthalmic beta-blockers and verapamil.
How serious is the interaction between Metipranolol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure, especially in patients with conduction disease or heart failure; consider a non-beta-blocker glaucoma agent if bradycardia occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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