Drug interactions
Metoclopramide intranasal + Nalbuphine
Severity: Moderate
Metoclopramide intranasal and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and antagonize the prokinetic action of metoclopramide, and both can cause CNS effects such as drowsiness. The combination may reduce metoclopramide effectiveness and add to sedation.
What this interaction means in plain words
Metoclopramide intranasal and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated reduction in gastrointestinal motility opposes dopamine antagonist prokinesis, with additive CNS effects.
What to do
Monitor for reduced gastroparesis control and for sedation. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Metoclopramide intranasal with Nalbuphine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and antagonize the prokinetic action of metoclopramide, and both can cause CNS effects such as drowsiness. The combination may reduce metoclopramide effectiveness and add to sedation.
How serious is the interaction between Metoclopramide intranasal and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced gastroparesis control and for sedation. Use the lowest effective doses.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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