Drug interactions
Metoclopramide intranasal + Procarbazine
Severity: Major
Metoclopramide intranasal and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may provoke catecholamine release and can enhance hypertensive reactions in patients on MAO inhibitors such as procarbazine. This could cause hypertensive crisis in susceptible patients.
What this interaction means in plain words
Metoclopramide intranasal and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Metoclopramide-associated catecholamine release combined with MAO inhibition may lead to pressor responses.
What to do
Avoid the combination and use another antiemetic such as ondansetron, with attention to serotonergic risk. If it cannot be avoided, monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Procarbazine?
MediHelp rates the interaction as major. Metoclopramide intranasal and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide may provoke catecholamine release and can enhance hypertensive reactions in patients on MAO inhibitors such as procarbazine. This could cause hypertensive crisis in susceptible patients.
How serious is the interaction between Metoclopramide intranasal and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use another antiemetic such as ondansetron, with attention to serotonergic risk. If it cannot be avoided, monitor blood pressure closely.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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