Drug interactions
Metoclopramide intranasal + Quetiapine
Severity: Major
Metoclopramide intranasal and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide blocks dopamine D2 receptors, and combining it with an antipsychotic increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Quetiapine has low D2 affinity but the additive risk remains.
What this interaction means in plain words
Metoclopramide intranasal and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central dopamine D2 receptor antagonism.
What to do
Avoid combining where possible and use a non-dopamine-blocking antiemetic or prokinetic. If it must be used, monitor for movement disorders and rigidity or fever, and stop metoclopramide if they occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Metoclopramide intranasal with Quetiapine?
MediHelp rates the interaction as major. Metoclopramide intranasal and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide blocks dopamine D2 receptors, and combining it with an antipsychotic increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Quetiapine has low D2 affinity but the additive risk remains.
How serious is the interaction between Metoclopramide intranasal and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and use a non-dopamine-blocking antiemetic or prokinetic. If it must be used, monitor for movement disorders and rigidity or fever, and stop metoclopramide if they occur.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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