Drug interactions
Metoclopramide intranasal + Quinidine
Severity: Major
Metoclopramide intranasal and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a strong CYP2D6 inhibitor and raises metoclopramide exposure, increasing the risk of extrapyramidal effects, tardive dyskinesia, and sedation. The intranasal product has a fixed dose and cannot be adjusted to compensate.
What this interaction means in plain words
Metoclopramide intranasal and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Quinidine inhibits CYP2D6, reducing metoclopramide metabolism.
What to do
Avoid the combination and use a different formulation or antiemetic. If metoclopramide is needed, use an oral form with a reduced dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Quinidine?
MediHelp rates the interaction as major. Metoclopramide intranasal and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine is a strong CYP2D6 inhibitor and raises metoclopramide exposure, increasing the risk of extrapyramidal effects, tardive dyskinesia, and sedation. The intranasal product has a fixed dose and cannot be adjusted to compensate.
How serious is the interaction between Metoclopramide intranasal and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different formulation or antiemetic. If metoclopramide is needed, use an oral form with a reduced dose.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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