Drug interactions
Metoclopramide intranasal + Ramelteon
Severity: Moderate
Metoclopramide intranasal and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness, fatigue and other CNS effects, which may add to the sedation of ramelteon. The interaction is likely to be mainly additive and modest.
What this interaction means in plain words
Metoclopramide intranasal and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; no specific pharmacokinetic mechanism established.
What to do
Monitor for excessive drowsiness and advise against driving or hazardous tasks until response is known. Consider alternative antiemetic therapy if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Metoclopramide intranasal with Ramelteon?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness, fatigue and other CNS effects, which may add to the sedation of ramelteon. The interaction is likely to be mainly additive and modest.
How serious is the interaction between Metoclopramide intranasal and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and advise against driving or hazardous tasks until response is known. Consider alternative antiemetic therapy if sedation is problematic.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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