Drug interactions
Metoclopramide intranasal + Secobarbital
Severity: Moderate
Metoclopramide intranasal and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and metoclopramide both act on the central nervous system, and combined use may increase sedation and impair psychomotor performance. Metoclopramide can also cause extrapyramidal effects and drowsiness that may be compounded by a sedative-hypnotic.
What this interaction means in plain words
Metoclopramide intranasal and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects; no specific pharmacokinetic mechanism is established.
What to do
Counsel the patient about additive drowsiness and avoid driving or hazardous tasks. Monitor for excessive sedation and movement disorders, and reduce the dose of one agent if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Secobarbital?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and metoclopramide both act on the central nervous system, and combined use may increase sedation and impair psychomotor performance. Metoclopramide can also cause extrapyramidal effects and drowsiness that may be compounded by a sedative-hypnotic.
How serious is the interaction between Metoclopramide intranasal and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and avoid driving or hazardous tasks. Monitor for excessive sedation and movement disorders, and reduce the dose of one agent if they occur.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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