Drug interactions
Metoclopramide intranasal + Sertraline
Severity: Moderate
Metoclopramide intranasal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal symptoms and has been associated with serotonin syndrome and neuroleptic malignant syndrome when combined with SSRIs. SSRIs can also raise metoclopramide exposure by inhibiting CYP2D6, increasing the risk of dyskinesia.
What this interaction means in plain words
Metoclopramide intranasal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic effects, with sertraline inhibition of CYP2D6 raising metoclopramide levels.
What to do
Monitor for movement disorders, agitation and signs of serotonin toxicity. Consider a lower metoclopramide dose or an alternative antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Sertraline?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal symptoms and has been associated with serotonin syndrome and neuroleptic malignant syndrome when combined with SSRIs. SSRIs can also raise metoclopramide exposure by inhibiting CYP2D6, increasing the risk of dyskinesia.
How serious is the interaction between Metoclopramide intranasal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, agitation and signs of serotonin toxicity. Consider a lower metoclopramide dose or an alternative antiemetic if symptoms develop.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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