Drug interactions
Metoclopramide intranasal + Tranylcypromine
Severity: Major
Metoclopramide intranasal and Tranylcypromine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may enhance the hypertensive effect of MAO inhibitors, and its labeling lists MAOIs as a concern because of possible catecholamine release. The combination may cause marked elevations in blood pressure.
What this interaction means in plain words
Metoclopramide intranasal and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Metoclopramide may stimulate catecholamine release, which MAO inhibition potentiates.
What to do
Avoid the combination and use an alternative antiemetic such as ondansetron if suitable, bearing in mind its serotonergic effect. If unavoidable, monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Tranylcypromine?
MediHelp rates the interaction as major. Metoclopramide intranasal and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide may enhance the hypertensive effect of MAO inhibitors, and its labeling lists MAOIs as a concern because of possible catecholamine release. The combination may cause marked elevations in blood pressure.
How serious is the interaction between Metoclopramide intranasal and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiemetic such as ondansetron if suitable, bearing in mind its serotonergic effect. If unavoidable, monitor blood pressure closely.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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