Drug interactions
Metreleptin + Theophylline
Severity: Moderate
Metreleptin and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin may alter CYP1A2-mediated theophylline clearance, so serum levels may rise or fall. Because of the narrow therapeutic range, toxicity (arrhythmias, seizures) or loss of efficacy may occur.
What this interaction means in plain words
Metreleptin and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metreleptin belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
Leptin may modulate CYP450 expression, including CYP1A2, changing theophylline metabolism.
What to do
Measure serum theophylline when metreleptin is started, changed or stopped and adjust the dose to the level and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metreleptin
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Metreleptin with Theophylline?
MediHelp rates the interaction as moderate. Metreleptin and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin may alter CYP1A2-mediated theophylline clearance, so serum levels may rise or fall. Because of the narrow therapeutic range, toxicity (arrhythmias, seizures) or loss of efficacy may occur.
How serious is the interaction between Metreleptin and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum theophylline when metreleptin is started, changed or stopped and adjust the dose to the level and clinical response.
What other medicines interact with Metreleptin?
MediHelp also lists interactions of Metreleptin with, for example, Insulin aspart, Insulin glargine-lixisenatide, Insulin glargine. The full list is on the Metreleptin page.
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