Drug interactions
Metronidazole + Naloxegol
Severity: Minor
Metronidazole and Naloxegol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-gp substrate, and moderate or strong CYP3A4 inhibitors raise its exposure and can cause opioid withdrawal-like symptoms and abdominal pain. Metronidazole is a weak inhibitor, so the effect is likely small.
What this interaction means in plain words
Metronidazole and Naloxegol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Theoretical weak CYP3A4 inhibition by metronidazole reducing naloxegol clearance.
What to do
No empirical dose change is needed. Watch for abdominal pain, diarrhea or opioid withdrawal symptoms and lower the naloxegol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Metronidazole with Naloxegol?
MediHelp rates the interaction as minor. Metronidazole and Naloxegol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naloxegol is a CYP3A4 and P-gp substrate, and moderate or strong CYP3A4 inhibitors raise its exposure and can cause opioid withdrawal-like symptoms and abdominal pain. Metronidazole is a weak inhibitor, so the effect is likely small.
How serious is the interaction between Metronidazole and Naloxegol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Watch for abdominal pain, diarrhea or opioid withdrawal symptoms and lower the naloxegol dose if they occur.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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