Drug interactions
Metronidazole + Nicardipine
Severity: Minor
Metronidazole and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is extensively metabolized by CYP3A4 and CYP2C9, so reduced clearance may cause hypotension, flushing, edema or tachycardia. Metronidazole is a weak inhibitor, so a significant effect is unlikely.
What this interaction means in plain words
Metronidazole and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Nicardipine belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP3A4 and CYP2C9 by metronidazole reducing nicardipine metabolism.
What to do
No routine adjustment is needed; monitor blood pressure and heart rate when starting or stopping metronidazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Metronidazole with Nicardipine?
MediHelp rates the interaction as minor. Metronidazole and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is extensively metabolized by CYP3A4 and CYP2C9, so reduced clearance may cause hypotension, flushing, edema or tachycardia. Metronidazole is a weak inhibitor, so a significant effect is unlikely.
How serious is the interaction between Metronidazole and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and heart rate when starting or stopping metronidazole.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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